The major outer membrane protein nucleotide sequence ofChlamydia trachomatis, serovar E
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چکیده
منابع مشابه
The major outer membrane protein nucleotide sequence of Chlamydia trachomatis, serovar E.
The major outer membrane protein (MOMP) of C. trachomatis is surface exposed and accounts for 60% of the outer membrane protein of this widespread pathogen. This protein has been shown to contain conserved regions among the 15 serovars of C. trachomatis as well as variable domains (VD) that are partially responsible for antigenic differences among the serovars. In addition antibodies raised to ...
متن کاملNucleotide sequence of the major outer membrane protein gene from Chlamydia trachomatis serovar H.
The gene encoding the major outer membrane protein (MOMP) from Chlamydia trachomatis, serovar H was isolated from a genomic library using the MOMP gene from serovar L2 as the probe (1) . The recombinant insert was subcloned into a plasmid vector (Bluescript), the gene localized by Southern blotting and the nucleotide sequence was determined by the dideoxy chain termination method. The H MOMP ge...
متن کاملSequence analysis of the major outer membrane protein gene from Chlamydia trachomatis serovar L2.
The structural gene for the major outer membrane protein (MOMP) from Chlamydia trachomatis was cloned and sequenced. A lambda gt11 recombinant (lambda gt11/L2/33) that contains a portion of the MOMP coding sequence was used to probe a lambda 1059 library constructed from DNA obtained from C. trachomatis serovar L2. Selected lambda 1059 recombinants were mapped with endonuclease restriction enzy...
متن کاملNucleotide sequence of the variable domains within the major outer membrane protein gene from serovariants of Chlamydia trachomatis.
During studies in which we serotyped large numbers of Chlamydia trachomatis clinical isolates by using monoclonal antibodies, three novel serological variants (D-, D*, and I-) were identified. To determine the molecular basis for the altered monoclonal antibody reactions of these strains and other previously identified variants (Da, Ia, and L2a), we determined the nucleotide sequences of the va...
متن کاملThe major outer membrane protein of a single Chlamydia trachomatis serovar can possess more than one serovar-specific epitope.
The major outer membrane proteins (MOMPs) of human Chlamydia trachomatis serovars exhibit four regions of variable amino acid sequences (VS1 to VS4) harboring serovar-specific B-cell epitopes. Antibody responses to these epitopes may contribute to acquired protection against human chlamydial infection. MOMP B-cell epitopes defined by 22 different serovar-specific or bispecific murine monoclonal...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1990
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/18.11.3414